Rapid synthesis of nucleotide pyrophosphate linkages in a ball mill.

نویسندگان

  • Francesco Ravalico
  • Ivano Messina
  • M Victoria Berberian
  • Stuart L James
  • Marie E Migaud
  • Joseph S Vyle
چکیده

Using a ball mill, rapid, atom-economic coupling between adenosine-5'-phosphoromorpholidate and phosphorylated ribose derivatives as their sodium or barium salts was achieved. Facile purification by reversed-phase HPLC enabled product isolation within hours.

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عنوان ژورنال:
  • Organic & biomolecular chemistry

دوره 9 19  شماره 

صفحات  -

تاریخ انتشار 2011